Unique features of bovine lymphocytes exposed to a staphylococcal enterotoxin
2006
Park, Y.H. (Seoul National University, Seoul, Republic of Korea) | Lee, S.U. (University of Idaho, Moscow, Idaho, USA) | Ferens, Witold A. (University of Idaho, Moscow, Idaho, USA) | Samuels, Sparrow (University of Idaho, Moscow, Idaho, USA) | Davis, William C. (Washington State University, Pullman, WA, USA) | Fox, Lawrence K. (Washington State University, Pullman, WA, USA) | Ahn, J.S. (University of Nebraska Medical Center, Omaha, NE, USA) | Seo, K.S. (University of Idaho, Moscow, Idaho, USA) | Chang, B.S. (Seoul National University, Seoul, Republic of Korea) | Hwang, S.Y. (Seoul National University, Seoul, Republic of Korea) | Bohach, Gregory A. (University of Idaho, Moscow, Idaho, USA), E-mail: [email protected]
We previously demonstrated that stimulation of bovine peripheral blood mononuclear cells (PBMCs) with staphylococcal enterotoxin C (SEC), led to an inversion of the CD4+:CD8+ T cell ratio and generation of an atypical CD8+ T cell subpopulation expressing CD26. In the present study, we examined T cell apoptosis and proliferation profiles of PBMC subpopulations in cultures stimulated with SEC. Unlike when stimulated with concanavalin A, nucleic acid synthesis in bovine PBMC cultures stimulated with SEC was low during the first four days but increased greatly on day 5. In contrast, nucleic acid synthesis in human PBMC cultures stimulated with SEC increased continuously.
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