Effect of Msp I polymorphism in RBP4 gene on litter size in pigs
2004
Omelka, R.,Univerzita Konstantina Filozofa, Nitra (Slovak Republic) | Peskovicova, D.,Vyskumny ustav zivocisnej vyroby, Nitra (Slovak Republic) | Bauerova, M.,Univerzita Konstantina Filozofa, Nitra (Slovak Republic) | Martiniakova, M.,Univerzita Konstantina Filozofa, Nitra (Slovak Republic) | Buchova, B.,Vyskumny ustav zivocisnej vyroby, Nitra (Slovak Republic) | Bulla, J.,Vyskumny ustav zivocisnej vyroby, Nitra (Slovak Republic)
Retinol-binding protein 4 (RBP4) is a major secretory product of the pig conceptus prior to implantation. The protein delivers an endogenous retinol (vitamin A) to target cells. RBP4 gene is expressed during the rapid morphological developmental period of pig blastocyst elongation which is a critical period for embryonic survival. This suggests that RBP4 may be an interesting candidate gene for litter size in pigs.We investigated the effect of Msp I polymorphism in the retinol-binding protein gene (RBP4) on total number of born (TNB), number of born alive (NBA) and number of weaned (NW) piglets in populations of Large White (LW) and Landrace (L) breeds from four Slovak breeding farms. Detection of the RBP4/Msp I genotypes was performed by PCR-RFLP method. The associations between the polymorphism and the reproductive traits were evaluated by linear model which included fixed and random effects. Frequencies of A allele were 0.52 in LW and 0.62 in L, respectively (Tab I). The A allele was favourable in both tested breeds, however, the effect on the traits was significant in Landrase sows only (Tab. II). Heterozygous boars had more piglets than homozygous (AA) but the effect was not confirmed statistically (Tab. III). According to the results we do not recommended RBP4/Msp I as the marker for litter size in pigs, however, the evaluation of larger population is necessary.
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Эту запись предоставил Technical University in Zvolen