Antitumor activities of low molecular weight fraction derived from the cultured fruit body of Sparassis crispa in tumor-bearing mice
2007
Yamamoto, K.(Unitika Ltd., Uji, Kyoto (Japan)) | Nishikawa, Y. | Kimura, T. | Dombo, M. | Matsuura, N. | Sugitachi, A.
Numerous reports concerning the antitumor activity of edible mushrooms have taken particular notice of beta-glucan; few studies have focused on antitumor-components other than beta-glucan. In the present study, we investigated the antitumor effects of a low molecular weight fraction (FHL) containing no beta-glucan isolated from the hot water extract of the cultured fruit body of Sparassis crispa. The oral administration of FHL to tumor-bearing mice was observed to suppress tumor growth. Furthermore, the interferon (IFN)-gamma level in the culture supernatant of splenic lymphocytes from FHL-fed tumor-bearing mice was significantly increased compared to a control group. Tumor-induced angiogenesis in the dorsal air sac (DAS) system was also suppressed by FHL administration. These results suggest that the oral administration of FHL induces antitumor activity through the enhancement of the Th1-response in tumor-bearing mice. Additionally, the anti-angiogenic activity of FHL may contribute to the antitumor activity of FHL.
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