Phosphate Number and Acyl Chain Length Determine the Subcellular Location and Lateral Mobility of Phosphoinositides
2006
Cho, H.N. (Kangwon National University School of Medicine, Chunchon, Republic of Korea) | Kim, Y.A. (Seoul National University College of Medicine, Seoul, Republic of Korea) | Ho, W.K. (Seoul National University College of Medicine, Seoul, Republic of Korea), E-mail: [email protected]
Phosphoinositides are critical regulators of ion channel and transporter activity. There are multiple isomers of biologically active phosphoinositides in the plasma membrane and the different lipid species are non-randomly distributed. However, the mechanism by which cells impose selectivity and directionality on lipid movements and so generate a non-random lipid distribution remains unclear. In the present study we investigated which structural elements of phosphoinositides are responsible for their subcellular location and movement.
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