Luteolin Inhibits Extracellular Signal-Regulated Kinase Pathway Through Protease-Activated Receptors (-2 and -4) and Their Agonist Activity
2007
Lee, S.H. (Wonkwang University, Iksan, Republic of Korea) | Sohn, Y.S. (Wonkwang University, Iksan, Republic of Korea) | Choi, Y.A. (Wonkwang University, Iksan, Republic of Korea) | Lee, J.E. (Chonbuk National University Medical School, Jeonju, Republic of Korea) | Kim, D.K. (Chonbuk National University Medical School, Jeonju, Republic of Korea) | Lee, Y.M. (Wonkwang University, Iksan, Republic of Korea), E-mail: [email protected]
Luteolin is a major flavonoid of Lonicera japonica and has anti-inflammatory effect. The activation of proteinase-activated receptor (PAR)-2 and -4 by trypsin appears to play a role in inflammation, In the present study, we examined the inhibitory effects of luteolin on activation of trypsin-induced human leukemic mast cells (HMC-1). HMC-1 cells were stimulated with trypsin, PAR-2 and PAR-4 agonist, in the presence or absence of luteolin. The level of TNF-α secretion was measured by enzyme-linked immunosorbent assay (ELISA).
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