A 43 kD Protein Isolated from the Herb Cajanus indicus L Attenuates Sodium Fluoride-induced Hepatic and Renal Disorders in Vivo
2007
Manna, Prasenjit (Department of Chemistry, Bose Institute, Acharya Prafulla Chandra Road, Kolkata, INDIA) | Sinha, Mahua (Department of Chemistry, Bose Institute, Acharya Prafulla Chandra Road, Kolkata, INDIA) | Sil, Parames C. (Department of Chemistry, Bose Institute, Acharya Prafulla Chandra Road, Kolkata, INDIA), E-mail: [email protected]
The herb, Cajanus indicus L, is well known for its hepatoprotective action. A 43 kD protein has been isolated, purified and partially sequenced from the leaves of this herb. A number of in vivo and in vitro studies carried out in our laboratory suggest that this protein might be a major component responsible for the hepatoprotective action of the herb. Our successive studies have been designed to evaluate the potential efficacy of this protein in protecting the hepatic as well as renal tissues from the sodium fluoride (NaF) induced oxidative stress. The experimental groups of mice were exposed to NaF at a dose of 600 ppm through drinking water for one week.
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