Analysis of Single Nucleotide Polymorphisms of Leptin Gene in Hanwoo (Korean Cattle)
2007
Lee, J.M. (Konkuk University, Seoul, Republic of Korea) | Song, G.C. (Konkuk University, Seoul, Republic of Korea) | Lee, J.Y. (National Genome Research Institute, Korea National Institute of Health, Seoul, Republic of Korea) | Kim, Y.B. (Konkuk University, Seoul, Republic of Korea), E-mail: [email protected]
Leptin, the product of the obese (ob) gene, is an adipocyte-derived hormone for the regulation of whole- body energy storage and energy usage. It has been reported that the homozygous mutations in the gene for leptin (LEP) induce obesity and reduce energy expenditure. In cattle, LEP has significant roles directly or indirectly related with phenotypes such as body weight and fat deposits, therefore SNPs of LEP have been considered important genetic marker to estimate carcass fat content in cattle. In this study, SNPs were screened in LEP (2,222 bp) between intron 1 to 3'-UTR from 24 independent Hanwoo (Korean cattle) by PCR and DNA sequencing.
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