Effect of Yam Yogurt on Colon Mucosal Tissue of Rats with Loperamide-induced Constipation
2007
Jeon, J.R. (Yeungnam University, Daegu, Republic of Korea) | Kim, J.Y. (Yeungnam University, Daegu, Republic of Korea) | Choi, J.H. (Yeungnam University, Daegu, Republic of Korea), E-mail: [email protected]
The effects of lactic acid fermented yam yogurt (Yam/YG) on colon mucosal tissue were investigated in a loperamide-induced constipation rat models. Sprague-Dawley rats were fed for 6 weeks with 3 types of diets (normal, supplemented with lactic acid bacteria, and supplemented with Yam/YG), and were then administered loperamide intraperitoneally twice daily for 5 days. Administration of loperamide decreased fecal excretion and the moisture content of feces with increasing of numbers of pellets in the colon. On the histopathologic findings from hematoxylin and eosin (HnE) and alcian blue stainings, supplementation with Yam/YG resulted in the recovery of depleted goblet cells and mucin, and increased the numbers of Ki-67 positive cells, indicating restoration of colonic mucosa, through cell proliferation and crypt regeneration against damages observed in crypt epithelial cells of loperamide-induced rats.
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