Curcumin-induced Growth Inhibitory Effects on HeLa Cells Altered-by Antioxidant Modulators
2007
Hong, J.I. (Seoul Women's University, Seoul, Republic of Korea), E-mail: [email protected]
Curcumin (diferuloyl methane), originated rhizomes of Curcuma longa L. has been suggested as an anti-inflammatory and anti-carcinogenic agent. In the present study, modulation of cytotoxic effects of curcumin on HeLa cells by different types of antioxidants was investigated. Cytotoxic effects of curcumin were significantly enhanced in the presence of superoxide dismutase (SOD) by decreasing IC∧50 to 15.4 from 26.0 μM after 24 hr incubation; the activity was not altered by catalase. The effect of curcumin was significantly less pronounced in the presence of 4 mM N-acetylcysteine (NAC).
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