Effect of different antimicrobials at therapeutic dose level on blood parameters of clinically normal and diseased sheep

The effect of amoxyciIlin, oxytetracycline and chloramphenicol at therapeutic dose level on the blood parameters of clinically normal and diseased (pyretic) sheep was studied in 18 febrile and 18 non febrile sheep for a period of 3 consecutive days. Amoxycillin treated diseased animals showed a gradual decline in temperature, pulse, respiration rate, neutrophil count, lymphocyte count, monocyte count and total serum protein, while total erythrocyte count, packed cell volume, total leukocyte count, eosinophil count and basophil counts were increased. In oxytetracycline treated affected animals, temperature, pulse, total erythrocyte count, neutrophil count, monocyte count, basophil count and total serum protein decreased while respiration rate, packed cell volume, total leukocyte count, lymphocyte count and eosinophil count increased gradually with time. In chloramphenicol treated pyretic animals temperature, pulse, respiration rate, total eryth rocyte count, total leukocyte count, neutrophil count, lymphocyte count, basophil count and total serum protein decreased and packed cell volume and eosinophil increased while no effect was noted on monocyte count from day zero progressively. In amoxycillin treated non affected animals, total erythrocyte count, packed cell volume, neutrophils, lymphocytes, monocytes and eosinophil increased while pulse, total leukocyte count and total serum protein decreased and no effect was observed on temperature, respiration and basophil count. In oxytetracycline treated normal animals pulse, respiration rate, total erythrocyte count, packed cell volume, total leukocyte count and eosinophil increased while neutrophil and total serum protein decreased gradually and there was no effect on temperature, lymphocytes, monocytes and basophiIs. In chloramphenicol treated clinically normal animals, pulse, lymphocytes, monocytes and eosinophil increased while total erythrocyte count, total leukocy t e count, neutrophil and total serum protein values decreased from day zero to onward. But there was no effect on temperature, respiration rate, packed cell volume and basophil count from day zero to day second.