[Using tylosin-containing preparations for dysentery in pigs]
2007
Shakhov, A.G. | Zuev, N.P. | Bukhanov, V.D. | Logachiev, A.V.,All-Russia Research and Development Veterinary Inst. of Pathology, Pharmacology and Therapy, Voronezh (Russian Federation)
Four strains of Brachispira hyodysenteriae were evaluated for susceptibility to tylosin-containing preparations and farmazine was evaluated for prophylactic efficacy on dysentery of young pigs. As is shown, Brachispiras are susceptible to tylan in the concentration of 6.25 microg/ml, to tylosin base, fradizine, farmazine and tylosin tartrate from 15.92 to 75.0 microg/ml. The minimum bactericidal concentration of farmazine for four B. hyodysenteriae strains F1, F2, F3 and K1 was 40.33; 75.0; 33.45 and 33.45 microg/ml, relatively. For acute disease farmazine was used at the dose of 20 mg/kg of body weight once a day during 3 days. Farmazine has been found to reach its maximum concentration in the blood serum of young pigs at the first 3 hours, in organs and tissues – during 3-24 h and was released with feces for more than 48 h. Therefore, the slaughter of pigs for meat is recommended to perform not earlier 6-7 days after 3-day long treatment. A single injection of farmazine at the dose of 20 mg/kg prevented infection of healthy pigs being in contact with sick pigs with dysentery. Farmazine given perorally was inefficient, as it may be accompanied with vomit. The resultant data testify that using a 10% water solution at the dose of 20 mg/kg once for the prophylactic purpose, and thrice – for the therapeutic purpose was efficient.
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