Modeling and simulation of the bioprocess with recirculation
2007
Zerajic, S., Faculty of Technology, Leskovac (Serbia) | Cvetkovic, D., Faculty of Technology, Leskovac (Serbia) | Mladenovic, I., Faculty of Technology, Leskovac (Serbia)
In this paper the simulation model of recirculation bioprocess was developed, which may be applied for increasing the biomass productivity and product biosynthesis, increasing the conversion of a substrate-to-product, mixing efficiency and secondary CO2 separation. The goal of the work is optimal bioprocess configuration, which is determined by simulation optimization. The optimal chemostat state was used as referent. Step-by-step simulation method is necessary because the initial bioprocess state is changing with recirculation in each step. The simulation experiment confirms that at the recirculation ratio alfa=0.275 and the concentration factor C=4 the maximum glucose conversion to ethanol and at a dilution rate ten times larger.
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