Evaluation of the genotoxic effects of thyroxine using in vivo cytogenetic test of Swiss albino mice
2007
Djelic, N., Faculty of Veterinary Medicine, Belgrade (Serbia) | Nesic, I., Institute of Immunology and Virusology Torlak, Belgrade (Serbia) | Stanimirovic, Z., Faculty of Veterinary Medicine, Belgrade (Serbia) | Jovanovic, S., Faculty of Veterinary Medicine, Belgrade (Serbia)
The aim of the present study was to further evaluate the possible genotoxic effects of thyroxine using in vivo cytogenetic test on Swiss albino mice. Three experimental concentrations of thyroxine were used (0.1 mg/kg, 0.5 mg/kg and 2.5 mg/kg). We treated mice for 1, 3, 7 or 10 days. Cytogenetic endpoinds (numerical and structural aberrations, chromosome gaps and breaks) were analysed in bone marrow cells from femures. The results obtained showed that thyroxine has not induced chromosome damage or aberrations. This is in agreement with our previous analysis of micronuclei in human peripheral blood lymphocytes treated with thyroxine. On the other hand, we observed a decrease of mitotic index especially in animals treated for a longer period of time with the highest dose of thyroxine. Therefore, it can be concluded that thyroxine does not induce genotoxic effects which could be detected by cytogenetic analysis.
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