Immunohistochemical analysis of cyclin E in Wilms tumors
2007
Radojevic-Skondric, S., School of Medicine, Belgrade (Serbia) | Djuricic, S., Institute for Mother and Child Protection Dr Vukan Cupic, Belgrade (Serbia) | Jovanovic, M., School of Medicine, Belgrade (Serbia) | Dimitrijevic, I., School of Medicine, Belgrade (Serbia) | Lazic, M., Clinical Hospital Center Dr Dragisa Misovic, Belgrade (Serbia) | Stojsic, Z., School of Medicine, Belgrade (Serbia) | Brasanac, D. | Basta-Jovanovic, G., School of Medicine, Belgrade (Serbia)
We have investigated 28 cases of Wilms tumor, two Wilms tumor metastases on lungs and one case of normal renal tissue. Correlation of semiquantitatively scored cyclin E levels with histopathological parameters was performed for all cases. Our findings suggest that diffuse expression of cyclin E is associated with the prognostic group and tumor stage. Also, cyclin E expression is more pronounced in the blastemal component than in the epithelial component. Diffuse expression of cyclin E is associated with an unfavourable outcome of Wilms tumor.
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