Changes in enzymes activity superoxid dismutase, glutathione reductase, reduced glutathione and quantity of malonil dialdehyde after acute aluminium poisoning
2007
Milovanovic, J., Clinical Center of Serbia, Belgrade (Serbia). Institute of Otorhinolaryngology and Maxillofacial Surgery | Milovanovic, A., Clinical Center of Serbia, Belgrade (Serbia). Institute for Occupational Health | Konstantinovic, Lj., Institute for Rehabilitation Dr Miroslav Zotovic, Belgrade (Serbia) | Djordjevic, V. | Stankovic, P. | Babic, B. | Arsovic, N. | Djukic, V., Clinical Center of Serbia, Belgrade (Serbia). Institute of Otorhinolaryngology and Maxillofacial Surgery
The important and increasing application of aluminium motivated us to determine whether and in what way does the antioxidative status of erythrocytes in aluminium acute poisoned animals change by studying the metabolism of superoxide dismutase (SOD), glutathione reductase (GR), reduced glutathione (GSH) and malonil dialdehyde (MDA). The experiment involved desert mice (gerbils) who received intraperitonally an aluminium chloride solution at a dose of 3.7 g/kg BM/ It has been noticed that during the course of the experiment SOD activity increased. We assume this represents a defense mechanism of the organism to increased quantities of free radicals. Further, aluminium considerably reduces the glutathione reductive system capacity affecting its enzymatic component, glutathione reductase which leads to a further decrease in reduced glutathione. The lipide peroxidation index expressed through MDA as an indicator of membrane status remains unchanged. This could mean that malonil dialdehyde is measured in erythrocytes not yet structurally damaged.
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