Morphometric changes of cardiac mast cells in rats acutely poisoned by T-2 toxin
2007
Jacevic, J., Military Medical Academy, Belgrade (Serbia). National Poison Control Center | Bokonjic, D., Military Medical Academy, Belgrade (Serbia). National Poison Control Center | Stojiljkovic, M., Actavis Trading Ltd., Belgrade (Serbia). Representative Office | Resanovic, M., Faculty of Veterinary Medcine, Belgrade (Serbia) | Bocarov-Stancic, A., Bio-Ecological Center, Zrenjanin (Serbia) | Kilibarda, V., Military Medical Academy, Belgrade (Serbia). National Poison Control Center | Popovic, N., Olympus, Belgrade (Serbia)
Wistar rats were treated with T-2 toxin (1 LD50; 0.23 mg/kg sc) and the surviving animals were sacrificed on days 1, 3, 5, 7, 14, 21, and 28 after treatment. At each time, control animals were sacrificed, too. Cardiac mast cells, previously stained by Giemsa method, were analyzed in whole visual fields, magnification x40. The quantitative morphometric parameters of cardiac mast cells were evaluated. On the results obtained, it could be concluded that the chosen quantitative morphometric parameters of cardiac degranular mast cells are useful for the evaluation of the functional status of the rat heart during acute T-2 poisoning.
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