[Polysaccharides of yellow melilot]
2007
Sychiev, I.A. | Poryadin, G.V. | Smirnov, V.M.
Outline of chemical polysaccharide classification, chemical composition and properties, particularly those of plants, is given. The method of water-soluble polysaccharide complex (WPC) and pectin extraction out of yellow melilot plants is developed. The prior extraction was carried out by 60% ethanol solution, the one of WPC by hot distilled water and WPC precipitation (in vacuum rotary evaporator) by 96% ethanol solution. After WPC abstraction the pectin was recovered by 1% hot solution of lithium ammonium. The pectin was precipitated by 96% ethanol after the extract wascocentrated. The effect of WPC and pectin on health animals and those, suffering from anemia, aseptic inflammation or irradiated ones was studied. The experimental animals were mice and rats. Health animals were injected with polysaccharides in 0.5 g per kg rate during 8-10 days. Rat appetite raised, their muscular mass and physical efficiency (swim test) increased. ATPase activity and metabolism intensivity raised. Haemopoiesis was stimulated by WPC and pectin; monocyte number increased in 2.2-2.6 times , lymphocyte one on 11.6-21.5%, erythrocyte one on 26-32%, hemoglobin one on 32-38%. Thymus, bone marrow and spleen weight enlarged; their structure also changed that indicated on immune system raised activity. In case of anemia RNA number in cells of hemopoietic organs was increased by WPC and pectin; glycosaminoglycan and proteoglycan synthesis intensified, that improved the blood composition. In case of inflammation WPC and pectin speeded macrophage and monocyte synthesis and extraction, increased their functional activity. On the 7-8 day extremity capacity, erythrocyte sedimentation rate and leukocyte number normalized. Pectin was antiradiation-tread for the rates, irradiated by 400 r-units. It activated erythropoiesis and lymphopoiesis that effected on organ structure and blood promoted damaged organ structure restoration and normalization of blood composition.
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