Immunohistochemical expression of protein p16 in Wilms tumor
2008
Basta-Jovanovic, G., University of Belgrade, Belgrade (Serbia). School of Medicine | Suzic, S., University of Belgrade, Belgrade (Serbia). School of Medicine | Savin, M., Clinical Center of Serbia, Belgrade (Serbia). Institute for Nephrology | Petronijevic, N., University of Belgrade, Belgrade (Serbia). School of Medicine | Radonjic, N., University of Belgrade, Belgrade (Serbia). School of Medicine | Djuricic, S., Institute for Mother and Child Health Protection Dr Vukan Cupic, Belgrade (Serbia) | Jovanovic, M., University of Belgrade, Belgrade (Serbia). School of Medicine | Radojevic-Skondric, S., University of Belgrade, Belgrade (Serbia). School of Medicine
The aim of this study was to investigate the expression of protein p16 in the normal kidney, as well as in Wilms tumor by immunohistochemistry and to correlate the results with tumor stage, histological type and prognostic group. We have investigated 28 cases of Wilms tumor, two Wilms tumor metastases in the lungs and one case of normal renal tissue. Protein p16 was over expressed in 20 cases of Wilms tumor. Expression of p16 was less frequent in stages III/IV/V than in stages I/II, showing no statistically significant correlation (p is greater than 0.05). The correlation between p16 expression and the predominantly blastemal histological type was statistically significant and showed that in such cases tumor cells can proliferate even in the presence of p16.
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