Ultrastructural changes of the chicken lung's surfactant complex after aerosol vaccination against newcastle disease
2008
Kazachka, D., National Diagnostic and Research Veterinary Institute, Sofia (Bulgaria)
The ultrastructural changes flowing in the lung surfactant complex of broiler chickens at 25 days of age after aerosol vaccination with B1 strain of Newcastle disease virus (NDV) was studied. The dynamics of the ultrastructural changes of the surfactant complex were investigated on the 24th, 48th, 72nd hours, 6th, 8th, 15th and 21st days after the aerosol vaccination. The results of electron microscope studies confirmed that almost all components of lung surfactant complex were affected by aerosol vaccination. The absence or chaotic state of surfactant, apoptotic changes of pneumocytes II type, desquamation of some of them and presence of serofibrinous exudate in more of the air capillaries on the 24th - 72nd hours after aerosol vaccination have proved that the interaction of the vaccine virus and components of the lung surfactant complex were started during the first few hours. As a result an embarrassed breading, depression, gasping, coughing, sneezing and refuse of feeding were provoked. In the next 6-8 days the changes were connected with compensation processes of surfactant production and activation of lung defense system. During 15-21 days after vaccination the lung structure was restored which demonstrate the reversible type of apoptotic changes provoked by aerosol vaccination in contrast to the cases of wild NDV inspiration.
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Эту запись предоставил Institute of Agricultural Economics