Intrauterine administration of bacterial modulins : An alternative therapy for endometritis.
2004
Deori, S. | Kumar, H. | Yadav, M. C. | Rawat, M. | Srivastava, S. K., Indian Veterinary Research Institute, Izatnagar (India)
To study recovery of endometritis in cows following intrauterine administration of certain bacteria modulins prepared in laboratory, twenty-four cows with endometritis were randomly divided into four groups of six animals each. The animals of group-I were given 100 ¦ug lipopolysaccharide (LPS) of E. Coli (Sigma Chemicals Co., USA), group-II bacteria free filtrate (BFF) of Staphylococcus aureus isolated from endometritis cows in the laboratory on the day of estrus. The control group animals received saline of similar times. There was a significant increase in total leucocyte coount and the polymorphonuclear cells. The levels of immunoglobulins were higher in groups of animals that received LPS preparations but not in BFF-treated animals. A significant (P0.05) reduction in bacterial load was observed in all treatment groups at subsequent estrus. The overall conception rate tended to be higher in group-I as compared to group-II and III. This study demonstrated therapeutic efficacy of laboratory preparations of LPS of E. coli and BFF of Staphylococcus aureus in endometritis stimulating the mechanisms of uterine defense as evident by increased increased influx of PMN cells and immunoglobulin levels in uterine fluid of treated animals.
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Эту запись предоставил Indian Council of Agricultural Research