Intra-abdominal leiomyosarcoma in a ferret (Mustela Putorius Furo): Histopathological and immunohistochemical characterization
2008
Pezzolato, M.(Istituto Zooprofilattico Sperimentale del Piemonte, Torino (Italy)) | Varello, K. | Mascarino, D. | Bozzato, E. | Vascellari, M. | Bozzetta, E.
A 5 years old female ferret with an abdominal palpable mass confirmed at echo-graphic examination died during an explorative laparotomy. A single lymph-node-like nodule was found adjacent to the intestinal loops. The round mass well circumscribed, solid and white, histologically, at low magnification, appeared encapsulated and built up by a population of atypical spindle cells arranged in interwoven fascicles. The cells had high anisocytosis degree, moderate mitotic activity and prominent nucleoli. A central area of necrosis was present. To characterise the tumour immunohistochemically cytokeratin, vimentin, S-100, melan-A, sub(v)WF, desmin, actin and alpha-actin were applied. Neoplastic cells resulted positive to vimentin, actin and alpha-actin. Based on the histological and immunohistological pattern a diagnosis of leiomyosarcoma was made.
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