Effect of CD4+CD25+ T cell-depletion on acute lethal infection of mice with Trypanosoma congolense
2008
Namangala, B.(Obihiro Univ. of Agriculture and Veterinary Medicine, Hokkaido (Japan)) | Yokoyama, N. | Ikehara, Y. | Taguchi, O. | Tsujimura, K. | Sugimoto, C. | Inoue, N.
Despite the immense socio-economic repercussions of African trypanosomosis (AT), there is currently no effective control measure against the disease. Characterization of mechanisms governing resistance and/or susceptibility to AT could suggest interventions that might lead to more effective disease control. The present study was designed in an attempt to address the possible role of CD4sup(+)CD25sup(+) T cells during an acute lethal infection of mice with Trypanosoma congolense, the causative agent of AT in domestic animals, through selective depletion using anti-CD25 monoclonal antibody. Accordingly, CD4sup(+)CD25sup(+) T-cell-depletion resulted in a significant reduction or delay in parasitemia, pathology, and mortality, as compared to controls. The apparent resistance in CD4sup(+)CD25sup(+)-T-cell-depleted mice correlated with a profound suppression of Th2 cytokines in vitro and in vivo, culminating in a net Th1 cytokine environment. Cumulatively, these findings suggest that CD4sup(+)CD25sup(+) T-cell- depletion improves the trypanotolerance of highly susceptible BALB/c mice acutely infected with the lethal T. congolense.
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