The effect of triclosan and 3-methyl-4-isopropylphenol in combination on axillary microflora
2008
Endo, Y.(Mandom Corp., Osaka (Japan). Central Research Labs.) | Okamoto, H. | Okada, F.
The effect of bactericides used in combination on axillary microflora and the effects of sebum components on the bactericidal effect were evaluated. The minimum bactericidal concentrations (MBC) of 2,4,4'-trichloro-2'-hydroxy diphenyl ether (Triclosan), 3-methyl-4-isopropylphenol (IPMP) and the combination of these 2 bactericides on axillary microflora were determined with or without the addition of oil ingredients. Triclosan showed a low MBC in the absence of the oil ingredient but the MBC increased in a dose-dependent manner in the presence of the oil ingredient, indicating the inhibition of the bactericidal effect. By contrast, IPMP showed a higher MBC than Triclosan in the absence of the oil ingredient but it was not significantly affected by the oil ingredient. Moreover, the combination of Triclosan and IPMP showed complementary effects of the respective bactericides in the absence and presence of the oil ingredient. This combination also showed a synergistic effect on the bactericidal potencies in the presence of the oil ingredient. These results suggest that the effect of Triclosan and IPMP in combination would exhibit satisfactory and broad bactericidal effects on the skin with variable amounts of sebum and sweat. This technique is expected to be a useful tool applicable to new deodorant products.
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