A case of persistent muellerian duct syndrome with Sertoli cell tumor and hydrometra in a dog
2009
Matsuu, A.(Tottori Univ. (Japan). Faculty of Agriculture) | Hashizume, T. | Kanda, T. | Nagano, M. | Sugiyama, A. | Okamoto, Y. | Hikasa, Y.
A 10-year-old Miniature Schnauzer with bilateral cryptorchidisim and male external genitalia was referred with a history of abdominal enlargement. Upon exploratory laparotomy, two tumors and a connecting structure similar to fluid-filled uterus were recognized. After cytological and bacterial examinations of the fluid and histological examination, this dog was diagnosed with bilateral Sertoli cell tumor with hydrometra. The karyotype of this dog was 78, XY and the sry gene was detected positive by PCR. We diagnosed this dog as a case of persistent Muellerian duct syndrome (PMDS), which is male pseudohermaphroditism. This is the first report regarding the incidence of PMDS in Miniature Schnauzers in Japan, and it suggests the involvement of a gene carrier.
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