Extract from Acanthopanax senticosus Harms (Siberian ginseng) activates NTS and SON/PVN in the rat brain
Soya, H.(Tsukuba Univ., Ibaraki (Japan)) | Deocaris, C.C. | Yamaguchi, K. | Ohiwa, N. | Saito, T. | Nishijima, T. | Kato, M. | Tateoka, M. | Matsui, T. | Okamoto, M. | Fujikawa, T.
The extract of the stem bark of Siberian ginseng, Acanthopanax senticosus Harms (ASH), is believed to play a body-coping role in stress through a brain noradrenergic mechanism. The present study was carried out to investigate the effect of ASH on the neuronal activation patterns of c-Fos expression in the rat brain. With ASH administration, c-Fos accumulated in both the supraoptic nuclei (SON) and paraventricular nuclei (PVN), which regulate stress response. Only the caudal regions in the nucleus of the solitary tract (NTS), a locus innervating both the SON and PVN, were activated. Such a neuro-anatomical pattern associated with ASH suggests the possible involvement of these stress-related brain loci.
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