Histochemical evaluation of T-2 toxin-induced cardiotoxicity in rats: semiquantitative analysis
2009
Jacevic, V.M., Military Medical Academy, Belgrade (Serbia). National Poison Control Centre | Bocarov-Stancic, A.S., Bio-Ecological Center, Zrenjanin (Serbia) | Resanovic, R.D., University of Belgrade, Belgrade (Serbia). Faculty of Veterinary Medicine | Dragojevic-Simic, V.M., Military Medical Academy, Belgrade (Serbia). Centre for Clinical Pharmacology | Vukajlovic, A.M., Military Medical Academy, Belgrade (Serbia). National Poison Control Centre | Djordjevic, S.B., Military Medical Academy, Belgrade (Serbia). National Poison Control Centre | Bokonjic, D.R., Military Medical Academy, Belgrade (Serbia). National Poison Control Centre
The present study demonstrates that the subcutaneous administration of a single dose of 0.23 mg/kg (1 LD50) of T-2 toxin to Wistar rats results in myocardial damage, especially in massive hemorrhagic lesions and intesive degranulation of MCs, and provides new insights into the pathogenesis of these alterations. Moreover, the results point to the market complexity of the pathogenesis of these lesions. The results indicate that basic histochemical methods can be a useful tool for evaluation of T-2 toxin-induced cardiac damage, which is probably a result of complex inflammatory mechanisms, eventually leading to vascular lesions and myocardial necrosis, as well as for some potential cardioprotectors in the future.
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