Antimicrobial substances from marine blue sponge, Neopetrosia sp. | สารต้านจุลชีพจากฟองน้ำทะเลสีน้ำเงิน Neopetrosia sp.
2009
Ritthirong Prommas(Kasetsart University, Bangkok (Thailand). Faculty of Fisheries. Department of Marine Science) E-mail:[email protected] | Puntip Wisespongpand(Kasetsart University, Bangkok (Thailand). Faculty of Fisheries. Department of Marine Science) | Suriyan Tunkijjanukij(Kasetsart University, Bangkok (Thailand). Faculty of Fisheries. Department of Marine Science) | Pongtep Wilaipun(Kasetsart University, Bangkok (Thailand). Faculty of Fisheries. Department of Fisheries Products)
Nineteen fractions (76 percent) of blue sponge, Neopetrosia sp. extracted by column chromatography, had almost antimicrobial activity to Bacillus subtilis, Vibrio cholerae, Aspergillus niger and Trichophyton mentagrophytes. NEO_CC_07 and NEO_CC_08 fractions showed the unique activity against Candida albicans and Bacillus cereus. NEO_CC_18, NEO_CC_19, NEO_CC_21 and NEO_CC_22 fractions revealed antimicrobial activity against black tiger shrimp, Vibrio cholerae and V. fluvialis, moreover NEO_CC_21 and NEO_CC_22 fractions also showed broad spectrum and unique activity against human pathogens, Enterococcus faecalis, Staphylococcus aureus, Salmonella Typhimurium and plant pathogen, Rolstonia solanacearum. The pure compound separated using HPLC, NEO_ COMBINE _1_C displayed activity against B. subtilis, V. cholerae, A. niger and T. mentagrophytes. NEO_COMBINE_2_B showed antimicrobial activity against B. subtilis, V. cholera, while NEO_COMBINE_2_C also exhibited activity against B. subtilis and V. cholerae. Antimicrobial substances extracted from Neopetrosia sp. could be developed for treatment infectious diseases against human, marine shrimp and plant pathogens.
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