Conglutinin - an important element of natural immunity in ruminants (a review)
2010
Sliwa-Dominiak, J.,University of Szczecin (Poland). Dept. of Microbiology and Immunology | Tokarz-Deptula, B.,University of Szczecin (Poland). Dept. of Microbiology and Immunology | Niedzwiedzka-Rystwej, P.,University of Szczecin (Poland). Dept. of Microbiology and Immunology | Deptula, W.,University of Szczecin (Poland). Dept. of Microbiology and Immunology
Conglutinin represents a collectin appearing only in some mammals, including cattle. It plays an important role in resistance of hosts against microbes and parasites. It exhibits affinity toward saccharides present on the surface of bacteria, viruses, fungi and parasites and it mobilizes the mechanisms leading to their inactivation. It manifests also the unique ability of agglutinating complement- and antibody-coated erythrocytes. Moreover, it shows the ability to activate immune system cells, including the process of phagocytosis. The factors that determine the amount and activity of conglutinin in mammalian serum are also presented. The broad scope of conglutinin is genetically controlled and, therefore, this collectin may constitute a useful and crucial factor in cattle husbandry.
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