Evaluation of Humoral Immune Response to Foot-and-Mouth Disease Vaccination in Experimentally Infected Guinea Pigs with Trypanosoma evansi
2001
Shahsavandi,S., Razi Vaccine and Serum Reseach Institute. Tehran. Iran. | Salehizadeh, M., Razi Vaccine and Serum Reseach Institute. Tehran. Iran. | Ebrahimi, M.M., Razi Vaccine and Serum Reseach Institute. Tehran. Iran.
The primary and secondary antibody responses of Trypanosoma evansi infected guinea pigs, all lacking foot-and-mouth disease (FMD) antibodies, to an inactivated FMD vaccine containing O1, A-Mardabad and Asia1 virus strains was evaluated. In experiment 1, guinea pigs (group A) were infected and vaccinated against FMD simultaneously. In experiment 2, guinea pigs (group B) were infected then vaccinated on posttreatment day 7. Booster doses were injected 28 days after primary vaccination. Blood samples were obtained 21 days after primary vaccination and 15 days after the second in both experiments. Body weight gains were diminished significantly in experiment 2, whereas body weight gains of guinea pigs in experiment 1 did not differ from that in control guinea pigs. Only in experiment 2, the infected animals showed a significant suppression (P0.05) of humoral immune response to FMD virus after primary vaccination but the antibody titers were not significantly depressed until after secondary vaccination. The results indicate that T.evansi can depressed the immunity against FMD virus in guinea pigs. The animals in experiment 2 failed to achieve protective antibody titers of 1/16 after a primary does and secondary antibody responses of the some infected animals required more time to reach pick titers.
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