Oral Immunization against Diphtheria and Tetanus Infections by Fluid Dphtheria and Tetanus Toxoids
2000
Mirchamsy, H., Razi Vaccine and Serum Research Institute. Tehran. Iran | Hamedi, M., Razi Vaccine and Serum Research Institute. Tehran. Iran | Fateh, G., Razi Vaccine and Serum Research Institute. Tehran. Iran | Sassani, A., Razi Vaccine and Serum Research Institute. Tehran. Iran
The safety and neutralizing antibody responses of animal and human volunteers to oral immunization with purified diphtheria and/or tetanus toxoids associated with egg yolk or an adjuvant-like medicinal plant, London Rocket Seed, are discussed in the study. Purified diphtheria toxoid incorporated in egg yolk and mixed with a medical plant seed was used to orally immunized rabbits against diphtheria infection. Animals were partially immunized against a lethal diphtheria toxin challenge. The immunity was complete when gastric enzyme juices were inhibited before oral vaccination by aprotinin, a natural protease inhibitor. Rabbits and monkeys were orally immunized against both diphtheria and tetanus in the same way by pre-treatment with aprotinin. Adult volunteers receiving protease inhibitor before administration of oral toxoids have shown a significant rise in specific circulating antitoxins.
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