Neuronal degeneration and microglial activation in the ischemic dentate gyrus of the gerbil
2009
Moon, J.B., Kangwon National Univ., Chuncheon (Korea R.) | Lee, C.H. | Park, C.W. | Cho, J.H. | Hwang, I.K. | Yoo, K.Y. | Choi, J.H. | Shin, H.C. | Won, M.H.
In the present study, we investigated the time-course changes of neuronal degeneration and microglial activation in the gerbil dentate gyrus after transient cerebral ischemia using Fluoro-Jade B histofluorescence staining and immunohistochemistry for Iba-1. Fluoro-Jade B positive cells were observed from 6 hr and markedly increased 1 day after ischemia/reperfusion. Iba-1-immunoreactive microglia was increased and hypertrophied at early time, and Iba-1 immunoreactivity was highest at 2 days after ischemia/reperfusion. These results may be direct evidence on neuronal degeneration and microglial activation in the gerbil dentate gyrus after ischemia/reperfusion.
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