Antibody response in cattle after vaccination with an inactivated rabies vaccine
2009
Oh, Y.S. (Choong Ang Vaccine Laboratories, Daejeon, Republic of Korea), E-mail: [email protected] | Yang, D.K. (National Veterinary Research and Quarantine Service, Anyang, Republic of Korea) | Choi, H.W. (Choong Ang Vaccine Laboratories, Daejeon, Republic of Korea) | Kim, Y.H. (Chungnam National University, Daejeon, Republic of Korea)
Rabies is mainly transmitted to cattle by carnivores in Korea. Once clinical symptoms have occurred, the disease is almost invariably fatal but only protective by vaccination. This study is aimed to certify efficacy o cattle of one rabies vaccine(CaniShot∨® RV-F manufactured by CAVAC) which the efficacy was already certified on cats and dogs. Also it is purposed to compare with the efficacy on guinea pigs as laboratory animals. Ten guinea pigs among selected 20 guinea pigs were vaccinated once and measured by neutralizing antibodies at 21 DPI with controls. Five calves among 7 were vaccinated once and measured by the same way with 2 controls. As results, the vaccine induced protectable antibodies in guinea pigs as well as cattle with a single dose. Although these animals were not challenged, neutralizing antibodies are largely accepted as evidence of immunity.
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