Synthesis of Anthranilic Acid Derivatives as Prolyl Endopeptidase Inhibitors

Han, H.G., Kyung Hee University, Yongin, Republic of Korea; Yoon, H.R., Kyung Hee University, Yongin, Republic of Korea; Paik, Y.S., Kyung Hee University, Yongin, Republic of Korea

Synthesis of Anthranilic Acid Derivatives as Prolyl Endopeptidase Inhibitors

2009

Han, H.G., Kyung Hee University, Yongin, Republic of Korea | Yoon, H.R., Kyung Hee University, Yongin, Republic of Korea | Paik, Y.S., Kyung Hee University, Yongin, Republic of Korea

Anthranilic acid derivatives (3-5) containing the long chain components of N-stearoyl, -oleoyl, and -linoleoyl groups were synthesized for the study of prolyl endopeptidase (PEP, EC 3.4.21.26) inhibitory activity. Compounds 3-5 showed competitive PEP inhibition with IC∧50 values of 2.81, 4.07 and 3.64 μM respectively, and K∧i values of 1.62, 4.10 and 2.77 μM, respectively.

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Ключевые слова АГРОВОК

peptide peptides

Библиографическая информация

Опубликовано в

Journal of the Korean Society for Applied Biological Chemistry

Том 52 Выпуск 6 ISSN 1738-2203

Нумерация страниц

pp. 735-738

Другие темы

Peptidos; Anthranilic acid derivatives; Prolyl endopeptidase inhibitor; Anti-amnestic

Язык

Английский

Примечание

Summary(En)

1 tables

2ill., 9 ref.

Тип

ФАО АГРИС — международная информационная система по сельскохозяйственным наукам и технологиям

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Synthesis of Anthranilic Acid Derivatives as Prolyl Endopeptidase Inhibitors

2009

Ключевые слова АГРОВОК

Библиографическая информация