Camphor oil poisoning - spectral analysis of rat brain activity
2006
Grbic, G. | Culic, M. | Martac, Lj. | Kesic, S. | Sokovic, M., University of Belgrade, Belgrade (Serbia). Institute for Biological Research Sinisa Stankovic | Spasic, S., University of Belgrade, Belgrade (Serbia). Center for Multidisciplinary Studies | Djokovic, D., University of Belgrade, Belgrade (Serbia). Faculty of Chemistry
We have decided to detect the seizure brain activity induced by camphor essential oil in rats, as there are still reports of severe intoxication in humans by camphor. The experiments were performed on adult Wistar male rats. The surgery and the acute electrophysiological recordings were done under pentobarbital sodium anesthesia. Local field potentials of cerebral parietal cortex were recorded. The rats were injected by camphor essential oil (150-675 microl/kg b.w. in 1 ml of saline, i.p.). We analyzed by Fast Fourier Transform the digitized electrocortical signals before and up 2-3 h after essential oil administration at the sampling rate of 256 Hz. There was a great increase of the mean total power spectra, a relative increase of the power in delta range and decreases of theta and beta ranges when seizural activity with spikes and waves of large amplitude occurred at the level of cerebral cortex 5-30 min after administration of camphor oil at doses greater than 300 microl/kg b.w. It is necessary to investigate further the dose dependent effectiveness of each terpenoid constituent of camphor essential oil on brain activity in order to elucidate the relative safety of the usage of essential oils with these terpenoids.
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