Effects of acute cadmium toxicity on oxidative damage in nervous tissue
2009
Milovanovic, A. | Milovanovic, A. | Milovanovic, J., Clinical Center of Serbia, Belgrade (Serbia) | Cemerikic, D., Medical Faculty, Belgrade (Serbia). Institute for Pathophysiology | Novakovic, M., Medical Faculty, Foca (Bosnia and Herzegovina) | Petrovic, M., Clinical Center of Serbia, Belgrade (Serbia) | Jovanovic, A., Medical Faculty, Belgrade (Serbia) | Petronic, I., Clinical Center of Serbia, Belgrade (Serbia)
We tested the hypothesis that acute cadmium exposure would lead to increased oxidative damage in various brain regions. Adult male rats were treated either with a single dose of 50 ppm of CdCl2 (LD50), or a single dose of 100 ppm CdCl2 (LD50), against control group not exposed to Cd. The enzymatic activity of total and mitochondrial SOD, as well as GR was significantly and dose-depending decreased, but MDA content was shown only a moderate increase. Results demonstrated the harmful effects of acute Cd exposure, in the nervous tissue, through mechanisms of oxidative damage.
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