Serum concentrations of selected acute phase proteins and enzyme activities after injection of a combined mineral preparation in calves
2009
Tothova, Cs. | Nagy, O. | Seidel, H. | Kovac, G., University of Veterinary Medicine, Kosice (Slovak Republic)
The objective of this study was to evaluate the possible effects of various forms of injections of a combined mineral preparations in calves on changes in serum concentrations of selected acute phase proteins - haptoglobin (Hp) and serum amyloid A (SAA), as well as on changes in the activity of selected enzymes - creatine kinase (CK) and aspartate amino-transferase (AST). The changes in serum concentrations and activities of the aforementioned variables were evaluated after administration of the the recommended therapeutic dose of the mentioned preparation and its repeated administration, and compared with changes recorded after a double therapeutic dose and its repeated administration. Results indicate that tissue injury and muscle damage caused by repeated injections, predominantly at higher doses of drugs, may result not only in increased activities of some enzymes, but also in more marked changes in serum concentrations of certain acute phase proteins, particularly serum amyloid A.
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