Effects of cisplatin on lipid peroxidation and the glutathione redox status in the liver of male rats: the protective role of selenium
Trbojevic, I.S., University of Kragujevac, Kragujevac (Serbia). Faculty of Science, Institute of Biology and Ecology | Ognjanovic, B.I., University of Kragujevac, Kragujevac (Serbia). Faculty of Science, Institute of Biology and Ecology | Djordjevic, N.Z., University of Kragujevac, Kragujevac (Serbia). Faculty of Science, Institute of Biology and Ecology | Markovic, S.D., University of Kragujevac, Kragujevac (Serbia). Faculty of Science, Institute of Biology and Ecology | Stajn, A.S., University of Kragujevac, Kragujevac (Serbia). Faculty of Science, Institute of Biology and Ecology | Gavric, J.P., Institute for Biological Research Sinisa Stankovic, Belgrade (Serbia) | Saicic, Z.S., Institute for Biological Research Sinisa Stankovic, Belgrade (Serbia)
The role of oxidative stress in cisplatin (CP) toxicity and its prevention by pretreatment with selenium (Se) was investigated. Male Wistar albino rats were injected with a single dose of cisplatin (7.5 mg CP/kg b.m., i.p.) and selenium (6 mg Se/kg b.m., as Na2SeO3, i.p) alone or in combination. The results suggest that cisplatin intoxication induces of oxidative stress and alters the glutathione redox status: reduced glutathione (GSH), oxidized glutathione (GSSG), and the GSH/GSSG ratio (GSH RI), resulting in increased lipid peroxidation (LPO) in rat liver. The pretreatment with selenium prior to CP treatment showed a protective effect against the toxic influence of CP on peroxidation of the membrane lipids and an altering of the glutathione redox status in the liver of rats. From our results we conclude that selenium functions as a potent antioxidant and suggest that it can control CP-induced hepatotoxicity in rats.
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