Combined effect of GSTM1 gene deletion, GSTT1 gene deletion and MTHFR C677T mutation in male infertility
Đorđević, V., Institute of Molecular Genetics and Genetic Engineering, Belgrade (Serbia) | Nikolić, A., Institute of Molecular Genetics and Genetic Engineering, Belgrade (Serbia) | Ljujić, M., Institute of Molecular Genetics and Genetic Engineering, Belgrade (Serbia) | Nestorović, A., Institute of Molecular Genetics and Genetic Engineering, Belgrade (Serbia) | Ristanović, M., Faculty of Medicine, Belgrade (Serbia) Institute of Human Genetics | Tulić, C., Clinical Center of Serbia, Belgrade (Serbia). Institute of Urology | Radojković, D., Institute of Molecular Genetics and Genetic Engineering, Belgrade (Serbia)
The aim of the study was to investigate the association between the GSTM1 and GSTT1 gene deletion and MTHFR C677T mutation and male infertility. The study has encompassed 52 infertile and 56 fertile males. Genotype distributions of GSTM1 and GSTT1 gene deletions and the MTHFR C677T mutation did not differ significantly among the analysed groups, however, a difference in distribution of certain genotype combinations was observed. The obtained results indicate that carriers of double GSTM1/GSTT1 deletion and the MTHFR 677CC genotype are at higher risk of infertility than carriers of any other combination of genotypes (OR 3.5, 95%CI 0.68-18.30).
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