Оценка иммунного ответа у цыплят, привитых мукозальными вакцинами против ньюкаслской болезни
2009
Volkova, M.A. | Irza, A.V. | Runina, I.A. | Frolov, S.V. | Kachalova, M.E. | Chvala, I.A. | Chubukova, E.I. | Mudrak, N.S. | Borisov, V.V. | Drygin, V.V., Federal Centre for Animal Health, Yurievets (Russian Federation)
Recently there were developed mucosal vaccines comprising an inactivated virus and virus antigens administered intranasally or perorally with adjuvants having muco-adhesive properties able of penetrating through mucous membranes. They are chitosan and particles of calcium phosphate (CAP) tested with a positive effect. The dynamics of the immune response creation in 20-day-old chicks following administration of experimental samples of Newcastle disease mucosal vaccines via mucous membranes was investigated. The mucosal immune response in chicks, immunized by preparations with an adjuvant, was stronger as compared with that in chicks, vaccinated by antigen without an adjuvant. Maximum IgG and IgM levels were observed in secretory fluids in 1-2 weeks following the last vaccination and maximum IgG levels were observed in 3-4 weeks following the last immunization. Chicks, vaccinated by preparations with mucosal adjuvants, demonstrated an increase of the amount of subpopulation CDS. Mucosal vaccines protected chickens against challenge by Newcastle disease highly virulent virus. The most immunogenic was estimated vaccine + CAP. The preparations will be further tested for more number of poultry.
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