Pharmaco-toxicological estimation and efficiency of Tilocolin at colibacteriosis and salmonellosis of calves | Фармако-токсикологическая оценка и эффективность тилоколина при колибактериозе и сальмонеллезе телят
2010
Shabunin, S.V. | Vostroilova, G.A. | Belyaev, V.I. | Alekhin, Yu.N. | Sashnina, L.Yu. | Kabitskij, S.N. | Nizhegorodov, M.Yu., All-Russia Research and Development Veterinary Inst. of Pathology, Pharmacology and Therapy, Voronezh (Russian Federation)
The therapeutic efficiency of a complex preparation of Tylocolin at colibacteriosis and salmonellosis of calves at farms of the Voronezh and Oryol regions unsafe from these diseases was studied. According to a pharmaco-toxicological evaluation of Tylocolin has shown that it does not possess irritating, allergenic, embryotoxic and teratogenic effects, with a wide spectrum of antimicrobial effects against Gram- and Gram+ microorganisms. It is low toxic. The therapeutic efficiency was estimated by the number of recovered calves and treatment terms compared to Enrocoli (for colibacteriosis) and 5%enroxyl solution (for salmonellosis). During the treatment in the experimental calves there were observed a reduction in the degree of acidosis, anemia, endogenous intoxication, disseminated intravascular blood coagulability and cytolysis. So, the therapeutic efficiency of Tylocolin at colibacteriosis calves makes up 91,7 %, at recovery term of 3,6 days, at a salmo¬nellosis accordingly 93,8 % and 3,7 days and 5.5 days, respectively. It is concluded that the complex preparation of Tylocolin consisting of tylosin, sulfate colistin, and a prolonging agent is more effective, inasmuch as it promotes the full-value process of calves' recovery than Enrocoli and 5%enroxyl solution according to the basic route when there are residual signs of metabolic disorders and hepatic insufficiency
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