Anti-oxidant and Anti-microbial Activities of Seungmakalgeuntang
2010
Lee, J.Y., Hoseo University, Asan, Republic of Korea | Bae, H.J., Daegu Haany University, Gyeongsan, Republic of Korea | Park, T.S., Daegu Gyeongbuk Institute for Oriental Medicine Industry, Gyeongsan, Republic of Korea | Kim, T.W., Andong National University, Andong, Republic of Korea | Moon, D.H., PioKorea Co., LTd., Daegu, Republic of Korea | Kwon, O.J., Gyeongbuk Regional Innovation Agency, Gyeongsan, Republic of Korea | Son, J.H., Daegu Gyeongbuk Institute for Oriental Medicine Industry, Gyeongsan, Republic of Korea | Lee, C.E., Daegu Haany University, Gyeongsan, Republic of Korea | Park, G.H., Daegu Haany University, Gyeongsan, Republic of Korea | Kim, H.H., Daegu Haany University, Gyeongsan, Republic of Korea | An, B.J., Daegu Haany University, Gyeongsan, Republic of Korea
Biological activities such as anti-oxidative and anti-microbial of the Seungmakalgeuntang, a traditional prescription, were evaluated. The electron donating ability of water, ethanol, supercritical fluid and 1,3-butylene glycol extract of Seungmakalgeuntang showed more than 50% at a 100 ppm concentration. At a 1000 ppm concentration, the superoxide dismutase-like activities of ethanol and supercritical fluid extract of Seungmakalgeuntang showed less than 50%. xanthine oxidase inhibition effect of the supercritical fluid extract showed more than 70% at a 1,000 ppm concentration, which was higher than vitamin C. From the measurement on lipid oxidation, the Fe²+ chelating abilities of the supercritical fluid extract of Seungmakalgeuntang was more than 60% at a 100 ppm concentration. Also the Cu²+ chelating abilities of supercritical fluid extract Seungmkalgeuntang was showed more than 60% at a 500 ppm concentration. Clear zones formed by sample against the human skin-resident microflora such as Staphylococcus epidermidis, Staphylococcus aureus and Propionibacterium acne of ethanol and supercritical fluid extract of Seungmakalgeuntang showed the highest among all the extracts tested using a 4 mg/disc. The minimum inhibitory concentration (MIC) against both S. epidermidis and S. aureus showed 2,500 ppm in the extract of the supercritical fluid.
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