Inhibitory Effect of Phosphatidylserine on Atopy-like Dermatitis in NC/Nga Mice
2010
Sur, B.J., Kyung Hee University, Seoul, Republic of Korea | Lee, B.B., Kyung Hee University, Seoul, Republic of Korea | Yeom, M.J., Kyung Hee University, Seoul, Republic of Korea | Han, J.J., Glonet BU, Doosan Co., Suwon, Republic of Korea | Choi, H.D., Korea Food Research Institute, Seongnam, Republic of Korea | Lee, H.J., Kyung Hee University, Seoul, Republic of Korea | Kim, S.J., Dongduk Women's University, Seoul, Republic of Korea | Yoon, S.H., Korea Food Research Institute, Seongnam, Republic of Korea | Hahm, D.H., Kyung Hee University, Seoul, Republic of Korea
In the present study, the anti-atopic effect of phosphatidylserine (PS) extracted from soybean was investigated in NC/Nga mice. The atopic symptoms were evaluated by scoring spontaneous scratching behavior and skin lesions, by measuring serum levels of immunoglobulin E (IgE) and interleukin-4 (IL-4), and by observing skin histology. After observing the maximum severity of atopic symptoms, PS was initiated. The PS treatment significantly alleviated apparent symptoms of atopic dermatitis and scratching behavior. The suppression of atopic dermatitis by PS was verified by decreases in the serum levels of IgE (p less than 0.05 after 8 weeks; p less than 0.001 after 9 weeks) and IL-4 (p less than 0.01 after 7 weeks; p less than 0.001 after 9 weeks). Histological observations also indicated that the thickening process of skin and the infiltration of inflammatory cells were significantly inhibited. Taken together, PS from soybean might be useful for alleviating atopic dermatitis symptoms and thus for developing a new medicine for treating human atopic disease.
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