Possible role of oxidative stress in acute cadmium hepatotoxicity in rats
2010
Mladenović, D., University of Belgrade, Belgrade (Serbia). School of Medicine | Radosavljević, T., University of Belgrade, Belgrade (Serbia). School of Medicine | Ninković, M., Military Medical Academy, Belgrade (Serbia). Institute for Medical Research | Vučević, D., University of Belgrade, Belgrade (Serbia). School of Medicine | Šljivančanin, T., University of Belgrade, Belgrade (Serbia). School of Medicine | Grbatinić, I., University of Belgrade, Belgrade (Serbia). School of Medicine | Ješić-Vukićević, R., Clinical Center of Serbia, Belgrade (Serbia). Institute for Digestive Diseases
The aim of our study was to investigate the role of reactive oxygen species and efficiency of antioxidant protection in rat liver in acute cadmium intoxication. In our study malondialdehyde concentration was elevated both in plasma and liver after cadmium administration (p is less than 0.01). Moreover, superoxide dismutase activity was increased in the cadmium-treated group, mainly due to increasean in copper/zinc superoxide dismutase activity (p is less than 0.01). Reduced gluthatione level in liver and plasma and concentration of sulfhydryl groups were not significantly changed by cadmium. The present study suggests that lipid peroxidation plays an important role in acute cadmium-induced liver injury. Antioxidant capacity of hepatocytes is partly increased due to an adaptive increase of superoxide dismutase activity.
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