[Pathomorphological and immunohistochemical examinations of lymph nodes in cattle naturally infected with leukaemia virus: M.Sc. thesis] | Patomorfološka i imunohistohemijska ispitivanja limfnih čvorova goveda prirodno inficiranih virusom leukemije: Magistarska teza
2008
Kukolj, V.
This work examines blood and lymph node samples from 32 cows, for which the presence of antibodies to the leukemia virus were proven in the blood sera. Full blood was used to make blood smears and a certain number of leukocyte and leukocyte formula. In the examined blood samples, leukocytosis and lymphocytosis was determined in four cows and lymphopenia in two. An increased percentage and a large number of immature lymphocytes were established in the blood smears of cows with lymphocytosis. In two cows, seropositive to the leukemia virus, a macroscopic examination of the lymph nodes revealed folicullar hyperplasia, and diffuse hyperplasia in four cows. Microscopic examinations of the lymph nodes of cows seropositive to the leukemia virus revealed the following: follicular hyperplasia, T zonal hyperplasia, hyperplasia of marrow cells, mixed type hyperplasia and depletion of lymphatic tissue. CD3+ T lymphocytes are immunodominant population of cells in lymph nodes with T zonal hyperplasia and in lymph nodes with marrow hyperplasia. CD79+ B lymphocytes are predominant cells in lymph nodes with expressed follicular hyperplasia. CD3+ and CD79+ lymphocytes are represented in larger numbers in lymph nodes with expressed mixed type hyperplasia. In lymph nodes with deplation was decrease expression CD3, CD79 and CD68 immunophenotype. Expresion CD5 molecule did not revealed in examined lymph nodes.
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