Effects of eight sulfated polysaccharides on infecting chicken embryo fibroblast of Newcastle disease virus | 8种硫酸化多糖对新城疫病毒感染鸡胚成纤维细胞能力的影响
2011
Wang Junmin, Nanjing Agricultural University, Nanjing(China) | Hu Yuanliang, Nanjing Agricultural University, Nanjing(China) | Zhang Fan, Nanjing Agricultural University, Nanjing(China)
Китайский. 摘 要：用氯磺酸-吡啶法修饰当归多糖（CAPS）和枸杞多糖（LBPS）,得到4种硫酸化当归多糖sCAPS0.6、sCAPS1.1、sCAPS1.9、sCAPS2.2和4种硫酸化枸杞多糖sLBPS0.7、sLBPS1.1、sLBPS1.5和sLBPS1.9。分别以CAPS和LBPS为对照,采用MTT法比较了这8种硫酸化多糖对新城疫病毒感染鸡胚成纤维细胞能力的影响。结果表明：硫酸化修饰能显著提高当归多糖和枸杞多糖的抗病毒活性,且与硫酸基取代度有一定的相关性。sCAPS2.2、sLBPS1.5、sCAPS1.9和sLBPS1.9的活性较好,可以作为进一步研究的材料。
Показать больше [+] Меньше [-]Английский. Chinese angelica polysaccharide（CAPS）and lycium barbarum polysaccharide（LBPS）were modified by chlrulfonic-pyridine method to obtain four sulfated CAPS,sCAPS0.6,sCAPS1.1,sCAPS1.9 and sCAPS2.2,and four sulfated LBPS,sLBPS0.7,sLBPS1.1,sLBPS1.5 and sLBPS1.9.The effects of eight sulfated polysaccharides on cellular infectivity of Newcastle disease virus（NDV）were compared by MTT method taking the non-modified CAPS and LBPS as controls.The results showed that sulfated modification could significantly enhance the anti-virus activity of CAPS and LBPS,which was correlated with the degree of sulfation of sulfated polysaccharide.sCAPS2.2,sLBPS1.5,sCAPS1.9 and sLBPS1.9 possessed better activity and would be as the materials for further research.
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