Body composition and brown adipose tissue in sedentary and active mice.
Bell R.R. | McGill T.
The influence of exercise on body composition, brown adipose tissue (BAT) activity and energy balance was studied in young female CD1 Swiss albino mice. Mice were divided into 2 groups with different levels of activity; Sedentary Controls (SC) were housed in standard mouse cages while the Active (A) group had free access to activity wheels. All mice were fed stock diet and after 6 weeks (Stock Period), energy intake, body composition and BAT were analyzed in half of the mice. The remaining mice continued in their same activity groups but were encouraged to overeat by cafeteria feeding with highly palatable human foods. Energy intake, energy balance, body composition and BAT were again measured after 2 weeks (Cafeteria Period). The Active group spent considerably more time in physical activity and consumed 18% more kJ during the Stock Period than the Sedentary Controls. Despite different levels of exercise and food intake, both groups had similar carcass energy content and BAT activity during the Stock Period. The SC group increased energy intake by 52% in response to cafeteria feeding while the A group increased energy intake by only 28%. The SC mice accumulated significantly more carcass fat than the A mice during the Cafeteria Period; SC, 15.1 +/- 1.2% and A, 9.0 +/- 0.4% carcass fat. The Active mice were better able to maintain body weight and energy balance when fed an energy dense diet. BAT activity was increased by cafeteria feeding (diet-induced hyperphagia) but was not affected by exercise (activity-induced hyperphagia).
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