Effect of high dietary nitrate on the disposition of sulfamethazine [4-amino-N-(4,6-dimethyl-2-pyrimidinyl)benzenesulfonamide] in swine.
Paulson G.D. | Aschbacher P.W.
Swine (58-74-kg initial weight) were fed a corn-soybean meal basal diet that contained 110 ppm sulfamethazine [4-amino-N(4,6-dimethyl-2-pyrimidinyl)benzenesulfonamide; sulmet] and 0, 10, 100, 500, or 1000 ppm nitrate. The concentrations of nitrite in the oral cavity and the concentrations of desaminosulfamethazine [N-(4,6-dimethyl-2-pyrimidinyl)benzenesulfonamide, DA-sulmet] in the blood were increased by feeding the highest levels of nitrate; however, 10 or 100 ppm of nitrate in the diet had little or no effect on nitrite and DA-sulmet concentrations in the oral cavity. Supplementing the diet with all levels of nitrate had little or no effect on the concentrations of sulmet and N4-Ac-sulmet in swine blood.
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