Effect of alpha-linolenic acid on diarrheal incidence in enterectomized rats enterally fed a liquid diet.
1996
Nakamura T. | Hayashi N. | Yoshihara D. | Yanai M. | Takeshita Y.
The effect on diarrheal incidence in enterectomized rats enterally fed a liquid diet of either perilla oil [alpha-linolenic acid (alpha-LnA)/linoleic acid (LA)=3.26], or corn oil [alpha-LnA/La-0.03], or both oils mixed together [alpha-LnA/La-0.32] was examined, together with the effect on the transit time through the digestive tract, and the effect on prostaglandin (PGE2 and PGF2alpha) and fatty acid concentrations. The incidence of diarrhea in the groups fed perilla oil or mixed oil was significantly lower than in the corn oil-fed group. Perilla oil or mixed oil-feeding resulted in longer transit times compared with corn oil-feeding. The concentrations of PGE2 in plasma and the colonic mucosa were lower in the perilla oil-fed group than in the corn oil-fed groups, while eicosapentaenoic acid levels in the colonic mucosa were higher in the perilla oil-fed group. These results indicate that an enterally-fed liquid diet enriched with alpha-LnA may prevent diarrhea after operations of the digestive tract accompanied by suppression of the motility of the digestive tract and alteration of the metabolism of fatty acids.
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