Effects of chlorocitrate on body weight in obese men on a metabolic ward.
Heshka S. | Nauss Karol C. | Nyman A. | Reisen K. | Kissileff H.R. | Porikos K.P. | Kral J.G.
Extract: Chlorocitrate has been shown to reduce food intake in lean and obese rats and lean dogs. The mechanism of action is believed to be peripheral through delayed gastric emptying which may partially mediate the anorectic effect. In this study, eight obese male volunteers (mean weight 117 kg, 164 per cent ideal body weight) (mean age 26 yr, range 19-40) were housed for 18 days on a metabolic ward. After 4 days of baseline acclimatization on placebo, the subjects received capsules of 300 mg chlorocitrate or placebo TID, 1 or 2 h before meals for 7 days in a double-blind, randomized, cross-over study. Total ad lib food intake was covertly monitored. A single test meal on an eating monitor was studied once during each condition. Multiple hunger ratings were obtained daily. Gastric emptying was studied with a scintillation camera. During chlorocitrate medication, subjects lost more weight or gained less versus placebo by an average of 1.6 kg/wk, in the face of a mean daily consumption of 4,510 kcal. During active drug administration, food intake was reduced only 1,650 kcal/wk. There were no reliable differences in hunger ratings or eating monitor measures, and gastric emptying was not delayed by the drug. Side-effects were few and insignificant. It is concluded that chlorocitrate has a pharmacological effect on body weight in man indicative of antiobesity activity.(author).
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