Virgin coconut oil for the prevention of sepsis among preterm neonates weighing 1500 g in UP-PGH [University of the Philippines-Philippine General Hospital] a randomized controlled trial
2007
Mantaring, J.B.V., Aurelio, M.A., Santiago, V.D., Philippine Univ. Manila, Padre Faura, Manila (Philippines). Dept. of Pediatrics
Medium chain triglyceride (MCT) oil has been used to augment weight gain among low birth weight infants. However, it is commercially unavailable. Virgin coconut oil (VCO) contains the most concentrated, natural source of MCT and lauric acid which has been documented to possess antibacterial, antiviral, anti-protozoal and anti-fungal properties. Neonates with birth weight less or equal to 1500 g, able to tolerate at least 50 ml/kg/day of enteral feedings, were included. After informed consent, subjects were randomized into either the VCO or control group. Both groups received preterm formula or breast milk. VCO was added at 0.5 ml/oz to the feedings of the treatment group. The outcomes were analyzed by intention to treat. A P-value 0.05 was considered statistically significant. The differences in duration of intervention, the occurrence of feeding intolerance, sepsis and death were among those measured. A total of 202 patients were included in this trial (103 in the treatment group and 99 in the control group) were included. There was no statistical difference in baseline characteristics. Sepsis was lower in the treatment group (14/103 (13.6%) vs. 26/99 (26.3%), P
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